Helpful Terms and FAQ

Here are some terms relating to the science behind AlloMap testing.

Gene: Basic unit of heredity found in your cells.

DNA: A chemical inside the nucleus of a cell that carries the genetic instructions. The DNA structure is a double stranded helix.

RNA: Delivers DNA’s genetic message from the nucleus to the cytoplasm where proteins are made.

Gene Expression: The process by which inheritable information from a gene, such as the DNA sequence, is made into a functional gene product, such as protein or RNA.

NPV (Negative Predictive Value): The proportion of people with a negative test who are free of the disease or condition.

Rejection: The process where your immune system fails to accept your transplanted organ as a part of your own body.

Click on the following questions to view the answers you need.

What is AlloMap testing?

AlloMap is an innovative test that uses a blood sample to help doctors manage the care of stable heart transplant recipients. When used together with standard clinical assessment, AlloMap can help inform your doctor whether you are at low probability of rejecting your heart at the time your blood was drawn.

What is the difference between genetic testing and gene expression testing?

Genetic testing covers tests that need to be evaluated to uncover genetic variations, mutations, traits and predispositions. This testing can also be used to predict an individual’s response to a therapy or other treatment.

Gene expression tests look for activation of genes—specifically measuring the amount of messenger RNA (mRNA) resulting from its corresponding gene. Because activation levels differ depending on the point in time, gene expression tests can be used multiple times. Each time the AlloMap test is performed, the gene expression of 20 genes (11 informative, 9 control) is measured.

How does AlloMap testing utilize gene expression?

AlloMap Molecular Expression Testing utilizes information from the expression level (the degree of activity) of 11 genes in a patient’s blood cells. Considered along with other clinical data, certain patterns of expression in these 11 genes have been shown to be associated with acute cellular rejection.

Where can I get AlloMap testing?

Ask your doctor or transplant coordinator if AlloMap testing is available at or near your transplant center.

What happens when my doctor orders AlloMap testing for me?

Once your doctor has decided AlloMap testing is right for you, your transplant coordinator will direct you to where you can have your blood drawn and processed. The blood sample will be drawn by trained staff and shipped to the XDx Reference Laboratory via overnight courier. After running the test, XDx will deliver the results to your doctor, typically within a day or two of receiving your sample.

If I have an AlloMap Test, will I be billed?

XDx will bill your insurer or medical center. For additional information, please go to the Health Insurance and Financial Assistance section.

Will my AlloMap test be covered by my insurer?

Many insurers, including Medicare, cover the cost of an AlloMap test. In the event that an insurer is not yet familiar with AlloMap and its benefits, then XDx’s reimbursement team can assist patients in getting the proper reimbursement.

For additional information, please go to Health Insurance and Financial Assistance section.

XDX - Expression Diagnostics

Helpful Terms and FAQ